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I understand that I can withdraw my consent at anytime. Please refer to our Terms of Use and Privacy Policy or Contact Us for more details.Activation of high affinity binding sites in membranes of lymphoid cells after cyclic nucleotide-dependent stimulation. The interaction of [3H]deoxyguanosine with lymphocyte membranes was studied under conditions when changes in cyclic AMP and cyclic GMP are known to occur in lymphocytes. The binding was transient, reaching a maximum at about 30 min, then declining to a steady state level. The pattern of loss of [3H]deoxyguanosine specific binding differed according to the type of cells studied. A close correlation was found between the maximum and the duration of the binding. It was found that cyclic nucleotides induced a decline of [3H]deoxyguanosine specific binding in membrane preparations of L6 rat myeloma cells, and that the binding was tightly coupled with the activation of adenylate cyclase. 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